Diabetic nephropathy is the serious diabetic complications, its clinical features are urine protein excretory rate increasing year by year, and renal hypofunction going to nephrosis in terminal stage. 糖尿病肾病是糖尿病的严重并发症,其主要临床特点为尿蛋白排泄率逐年增加、肾功能减退至终末期肾病。
Reversed-phase high performance liquid chromatography assay for determining 4 kinds of markers of diabetic nephro-pathy in urine 反相高效液相色谱法测定尿液4种肾病标志物
Results Compared with < 60 year group, ≥ 60 year group had more four-vessel coronary artery disease, more left main coronary artery ( LM) involvement, more severe diabetic retinopathy ( DR) and higher 24-hour microalbumin quantity in urine. 结果与<60岁组相比,≥60岁组冠状动脉四支血管病变及左主干(LM)受累多,糖尿病性视网膜病变(DR)严重,24h尿微量蛋白定量高;
Methods: Forty cases of DN were treated with diabetic diet, and to control the blood sugar and urine sugar in normal range with insulin. In addition, Forty cases were divided randomly into two groups: mai luo ning injection treatment group and ahylysantinfarctase treatment group. 方法:40例DN患者入院后给予治疗糖尿病饮食,用胰岛素控制血糖、尿糖在正常范围,并把40例DN患者随机分成脉络宁治疗组和蝮蛇抗栓酶治疗组。
In diabetic group, correlations were significantly positive among Ang-1, Tie-2, VEGF and TM-1. Meanwhile, they were positively correlated with kidney/ body weight, glomerular volume, glomerular area, and urine protein excretion respectively. 糖尿病组Ang-1、Tie-2、VEGF。和TM-1相互间均呈正相关,它们与尿蛋白、肾重/体重、肾小球体积、肾小球面积也均呈正相关。
Results: The expression of NF-κ B in diabetic rat was higher than that of normal control, number of positive cells expressing NF-κ B in renal tissue of diabetic rat showed a strong correlation with renal function and urine protein. 结果:糖尿病鼠肾组织NF-κB表达较正常肾组织明显增高,与尿蛋白及血肌酐增高呈正相关关系。
The result showed that it can reduce the high filtration of diabetic rat, control the hypertrophy of kidney, decrease the urine protein, ameliorate the mesenteric hyperplasia matrix of glomerulus and mesangial matrix hypertrophy of blood capillary. 结果:该药可降低糖尿病大鼠肾小球高滤过、控制肾脏肥大、减少尿蛋白、减轻肾小球系膜基质增生及毛细血管基底膜增厚。
Results The diabetic control rats showed increased urinary excretion of protein and TGF β_1 and NO level of plasma, urine and renal tissue and deposit of glomerular matrix, while atRA prevented these changes. 结果糖尿病对照组尿蛋白及TGFβ1排泄率、血清、尿液及肾组织NO水平和肾小球基质比例明显高于正常对照组,全反式维甲酸则减轻了这些变化。
Methods STZ induced diabetic rats were treated with Enalapril and the levels of urine protein, TGF β and AGEs in renal tissue were measured and compared. 方法以Enalapril治疗实验性糖尿病大鼠,并将正常组、糖尿病对照组及治疗组尿蛋白水平及肾组织转化生长因子β、糖基化终末产物含量进行比较。
For studying renal protective effects of the capsule, the diabetic rat condition was observed, blood biochemical indicators were detected, the urine microalbumin with the biochemistry, enzyme linked immunosorbent assay methods. 2. 运用生物化学、酶联免疫吸附法等实验技术,观察糖尿病大鼠的一般状态,检测血液生化指标、尿微量白蛋白等,研究解毒通络保肾胶囊对糖尿病大鼠肾脏的保护作用。